U.S. President Donald Trump said on Saturday (May 23, 2026) a deal with Iran had been “largely negotiated,” with the proposal including opening the crucial Strait of Hormuz, though the agreement was “subject to finalisation.” “An Agreement has been largely negotiated
A person who approached a White House security checkpoint and began firing at officers has died, according to federal officials. The U.S. Secret Service said in a statement late on Saturday (May 23, 2026) that, according to a preliminary investigation
After spending 35 years at , consumer chief marketing officer is preparing to leave the company following the end of its next fiscal year, according to an internal memo as reported by Business Insider.Mehdi told employees he would remain at Microsoft until June 2027 to support the company
Pakistani woman says corporate culture makes employees feel guilty for taking leave: ‘Rest needs justification’A Pakistani woman said corporate jobs made employees feel guilty for taking paid leaves they were allowed to use. Published on: May 24
This crunchy veggie rice paper pancake is the perfect quick-fix snack for sudden hunger cravings at home: Full recipeFrom crispy edges to flavour-packed bites, try this veggie rice paper pancake recipe for an ultimate comfort snack for lazy evenings. Updated on: May 24
Amazon techie earning ₹11 lakh/month has 1 house in US, 4 properties in India, Range Rover — but no emergency fundAn Amazon employee earning close to $300,000 feels financially insecure despite significant savings and investments. Published on: May 24
Rare lung transplant at Apollo saves a life; spotlight on India's organ donor shortageRare lung transplant at Apollo saves a life; spotlight on India's organ donor shortage Published on: May 24, 2026 10:33 AM IST PTI Share via Copy link New Delhi, A year ago, every breath felt borrowed
Editorial independence is core to our work. Some links may earn us a commission, without influencing our opinions.These countertop organisers, crockery pick and jars can give your kitchen a Pinteresty spin by keeping the clutter awayTurn your kitchen into a photo-ready space with stylish organisers
How Hormonal Shifts In Your 40s & 50s Increase Diabetes Risk, According To An Endocrinologist
How Hormonal Shifts In Your 40s & 50s Increase Diabetes Risk, According To An Endocrinologist
According to Dr. Saptarshi Bhattacharya, senior consultant, endocrinology, Indraprastha Apollo Hospitals, the risk of diabetes rises significantly in one's 40s and 50s due to a complex interplay of hormonal changes, metabolic slowdown, and evolving lifestyle patterns. This period often acts as a turning point when the body's internal regulatory systems particularly those linked to glucose metabolism and fat distribution begin to lose efficiency.
For women, Dr Bhattacharya explains that the transition into perimenopause and menopause leads to a sharp decline in estrogen levels. Estrogen plays a crucial role in maintaining insulin sensitivity and regulating fat storage. Once the hormone drops, most women tend to accumulate more visceral fat around the abdomen. This deep abdominal fat is metabolically active and releases inflammatory markers that interfere with insulin function. Lower estrogen levels also impact lipid metabolism, contributing to higher cholesterol and triglyceride levels, which further impair glucose regulation.
In men, Dr Bhattacharya notes that testosterone levels begin to dip more noticeably in the late 40s and 50s. Testosterone is essential for maintaining lean muscle mass and supporting the muscles' ability to efficiently absorb glucose. As levels decline, muscle mass decreases and fat mass increases, slowing overall metabolism. Low testosterone is strongly associated with insulin resistance and metabolic syndrome, major precursors to type 2 diabetes.
Across both genders, other hormonal systems shift with age. Levels of growth hormone decrease, reducing muscle mass and increasing fat accumulation. Concurrently, chronic stress and poor sleep elevate cortisol levels. As Dr Bhattacharya highlights, persistently high cortisol increases glucose production in the liver and weakens insulin's effectiveness, gradually raising blood sugar levels.
Body Composition Changes That Increase Diabetes Risk
Hormonal changes are accompanied by shifts in body composition. Sarcopenia, the age-related loss of muscle mass becomes more common in midlife. Since skeletal muscle is the primary site of glucose uptake, Dr. Bhattacharya emphasizes that reduced muscle mass significantly limits the body's ability to regulate blood sugar. Meanwhile, visceral fat increases around abdominal organs and releases inflammatory chemicals and adipokines that disrupt insulin signalling. These changes can happen even if total body weight is stable, which means individuals may not recognize their declining metabolic health. This is why endocrinologists now assess waist circumference and muscle-to-fat ratio rather than relying solely on weight.
Lifestyle Factors in Midlife That Elevate Risk
Lifestyle shifts in the 40s and 50s often amplify biological risks. Work demands typically peak during this phase, leaving less time for exercise. Sedentary habits weaken muscle strength and slow metabolism, making insulin resistance more likely. Sleep issues also become more common, women may struggle with insomnia due to menopause, while men face higher rates of obstructive sleep apnea.
Poor sleep disrupts hunger hormones, increases cravings for high-carbohydrate foods, and raises cortisol, all of which impair glucose control. Stress levels also escalate during midlife due to professional pressure, financial responsibilities, and caregiving burdens. Persistent stress drives abdominal fat gain and worsens insulin resistance. Dietary habits may worsen as well, with more irregular meals, processed foods, late-night snacking, and emotional eating. Even small yearly weight gains during this time can dramatically increase diabetes risk, as the added fat tends to be visceral.
Co-existing Conditions That Add to the Risk
The prevalence of metabolic conditions such as hypertension, dyslipidaemia, fatty liver disease, and thyroid dysfunction also rises in the 40s and 50s. Dr. Bhattacharya stresses that these conditions share pathways with insulin resistance. For instance, hypothyroidism slows metabolism and promotes weight gain, while fatty liver reduces the liver's ability to respond to insulin. Together, they create a cluster of cardiometabolic risks that accelerate the progression towards type 2 diabetes.
Why Screening and Prevention Are Crucial
Given these interconnected factors, Dr. Bhattacharya strongly recommends routine metabolic screening beginning in the early 40s. Important tests include fasting blood glucose, HbA1c, lipid profile, liver function tests, thyroid hormone levels, and waist circumference measurement.
Swipe Left For Next Video
Encouragingly, early intervention is highly effective. Regular exercise especially resistance training helps rebuild muscle mass and improve insulin sensitivity. Weight management, a balanced diet, proper sleep, and stress control also play critical roles. For individuals with high-risk factors, doctors may prescribe medications such as metformin or recommend vitamin D supplementation to prevent progression.
In essence, Dr Bhattacharya concludes that understanding how hormonal, metabolic, and lifestyle factors converge during midlife is essential for reducing diabetes risk and protecting long-term health.
Source: News18
Related Posts: PCB Names Test Captain Shan Masood As International Cricket Consultant These are the best rated laptops of 2025 according to users on Amazon Winter Diet According To Ayurveda Courtney Walsh Appointed As Bowling Consultant For This Team Ahead Of T20 WC 5 health benefits of line dancing – according to science Ex-Deloitte consultant explains why he lives in India despite having Canada PR What is your toxic trait according to your zodiac sign Abhijeet Bhattacharya Seeks Government's Help For Son Stuck In Dubai Amid Tensions PFC Independent Director Bhaskar Bhattacharya resigns Samik Bhattacharya Claims Anti-Incumbency In Bengal
Indian athletics witnessed a historic evening in Ranchi as Tejaswin Shankar became the first Indian ever to breach the 8000-point barrier in decathlon at the Federation Cup on Saturday. The 27-year-old produced a sensational all-round performance to finish with 8057 points
4 hours ago
The Centre released draft rules for the Viksit Bharat – Guarantee for Rozgar and Ajeevika Mission (Gramin) Act, 2025 for public consultation. The rules focus on governance, grievance redressal, and transitioning from MGNREGA to the new rural employment scheme
4 hours ago
The National Threat Analytics Unit of the Indian Cybercrime Coordination Centre (I4C) has warned of a sophisticated phishing campaign impersonating Apple tech support to target whose devices have been lost or stolen, officials said on Saturday.The I4C, which functions under the Union Home Ministry
4 hours ago
Sachin Tendulkar praised his son Arjun's IPL debut for Lucknow Super Giants. Arjun Tendulkar showed patience and skill in his first match. He bowled well and took a wicket. Sachin Tendulkar expressed pride in his son's performance and attitude
4 hours ago
White House shooting suspect claimed to be ‘real’ Osama bin Laden, threatened Trump online: ReportOsama bin Laden was the founder and leader of the terror group Al-Qaeda, which was reportedly responsible the 9/11 attacks. Updated on: May 24, 2026 11:02 AM IST By Anita Goswami Share via Copy
4 hours ago
May 24, Birthday Horoscope: Here's what the tarot cards have in store for youIf your birthday falls on May 24, here’s what your year ahead looks like, as per Tarot. Published on: May 24, 2026 11:00 AM IST By Kishori Sud Share via Copy link If you were born on May 24
4 hours ago
George Russell may have delivered the perfect answer to mounting pressure at Mercedes. After a fiery sprint race clash with championship-leading teammate Kimi Antonelli earlier on Saturday, the Briton bounced back in style to grab pole position for Sunday’s Canadian Grand Prix — edging the
4 hours ago
BJP candidate Debangshu Panda is leading significantly in the Falta assembly constituency repoll. After five rounds of counting, Panda has secured a lead of over 14,000 votes against his CPI(M) rival. The repoll followed allegations of EVM tampering and irregularities during the initial polling
4 hours ago
The suspect in a shooting near the White House was killed in an exchange of fire with Secret Service agents on Saturday evening, officials have confirmed. BBC's US media partner CBS has named the suspect as Nasire Best, a 21-year-old man who was known to the Secret Service and had a documented
4 hours ago
CPI(M) MP raises concerns over CBSE's digital evaluation, seeks interventionCPI(M) MP raises concerns over CBSE's digital evaluation, seeks intervention Published on: May 23, 2026 5:22 PM IST PTI Share via Copy link New Delhi, The Rajya Sabha leader of the CPI, John Brittas
4 hours ago
Imagine enjoying a decadent, fudge‑like treat that also supports your hormones, libido, and menstrual rhythm, all while being packed with collagen, magnesium, adaptogens, and lignan‑rich omega‑3s. These Seed Cycling Hormone Bliss Balls are designed around the simple yet powerful practice of
4 hours ago
Weekly Love Horoscope for May 24-30, 2026: The stars brings positive energies for these zodiac signsWeekly Love Horoscope for May 24-30, 2026: This week asks for patience, trust, and emotional resilience. Published on: May 24, 2026 7:30 AM IST By Kishori Sud Share via Copy link Aries Love feels
7 hours ago
Perhaps the fullest realisation of what Mohamed Salah has achieved at Liverpool will only come with time. But as he prepares to say his goodbyes on Sunday, there is plenty to appreciate and admire in the here and now. There are the standards Salah helped to set that emanated through the club in his
8 hours ago
From a darkly comic tale of revenge to a beautiful contemplation on friendship, here are the year's most acclaimed works of fiction so far. "Daring, deranged, cleverly written," is how Vogue describes the buzzy debut by Caro Claire Burke. In this satirical thriller
7 hours ago
Jaipur real estate: Ashiana Housing has launched the first phase of its 10.35-acre residential project ‘Ashiana Oma’ in Ajmer Road at Mansarovar Extension Ashiana Housing will invest nearly ₹560 crore to develop a residential project in Jaipur
7 hours ago
Overnight fires in Delhi: Shops, homes gutted in four blazesA fire department officer was injured after the tin shed of one of the shops he was standing on during the firefighting operation collapsed. Updated on: May 24, 2026 7:37 AM IST By Karn Pratap Singh Share via Copy link Four separate fire
7 hours ago
As per the government, the new rules enable families living in Delhi to submit applications if their annual household income is within the newly prescribed limit. New Delhi: The Delhi government has reopened the process of issuing fresh ration cards under changed eligibility criteria after a gap of
7 hours ago
The reported disruption of AI-animated film Critterz after OpenAI allegedly shut down Sora has sparked a larger conversation around one major issue in tech and entertainment: what happens when creators build entire projects on platforms they do not control?The reported disruption of AI-animated
7 hours ago
Ex-Meta employee says non-Chinese workers were targeted for layoffsA laid-off Meta engineer has alleged that he was routinely excluded and ostracised by his Chinese colleagues at the company. Updated on: May 24, 2026 7:01 AM IST By Sanya Jain Share via Copy link A laid-off Meta engineer has alleged
7 hours ago
Mackenzie Shirilla wanted Kim Kardashian's help; here's why it's not happeningMackenzie Shirilla sought Kim Kardashian's legal support following the release of The Crash documentary, but Kardashian reportedly has no plans to get involved. May 24, 2026
7 hours ago
The first scientific survey of fishing cats (Prionailurus viverrinus) in Kaziranga National Park and Tiger Reserve has recorded 57 individuals, confirming that the species is widely distributed and actively reproducing across the reserve’s floodplains
8 hours ago
X warns founder against reuploading White House shooting video: 'Revenue reduced by 90%'Nikita Bier of X warned a user against reuploading the White House shooting video, asking him to ‘Quote’ or ‘Video Reshare’ instead. Updated on: May 24, 2026 6:14 AM IST By Sanya Jain Share via Copy link
7 hours ago
Sonam Wangchuk says Article 371 talks for Ladakh still ‘work in progress’; backs Cockroach Janta PartySonam Wangchuk hoped constitutional safeguards will be granted to Ladakh after recent talks between Ladakh groups and the Centre. Updated on: May 24
7 hours ago
Talking about international partnerships, PM Modi said India’s growing ties with global companies and countries would create new opportunities for young people. Prime Minister Narendra Modi distributed more than 51,000 appointment letters to newly recruited candidates during the 19th Rozgar Mela
7 hours ago
The Archaeological Survey of India’s circular in December on tourist guides at Red Fort has opened a larger debate: who gets to interpret the past? The circular states that only guides licensed by the Ministry of Tourism and endorsed by the Archaeological Survey of India may offer services inside
8 hours ago
Dipika Kakar’s father-in-law in ICU after suffering stroke, Shoaib Ibrahim seeks prayers: ‘24 hrs are crucial’Shoaib Ibrahim took to Instagram to inform fans that his father has been hospitalised once again after suffering another stroke. May 24, 2026
7 hours ago
Oleksandr Usyk struck lucky to retain his world heavyweight titles in Egypt with a highly controversial 11th-round stoppage win against boxing novice Rico Verhoeven. Verhoeven, in just his second professional boxing fight, was the clear aggressor for long spells
8 hours ago
