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Ancient tooth proteins suggest Homo erectus may have left genetic legacy in people today
Ancient tooth proteins suggest Homo erectus may have left genetic legacy in people today
Ancient tooth proteins suggest Homo erectus may have left genetic legacy in people today
Ancient tooth proteins suggest Homo erectus may have left genetic legacy in people today
Published on: May 19, 2026 10:56 AM IST PTI Share via Copy link Poole , For most of the 20th century, the model of human origins was a tree: with the trunk dividing into branches, and then twigs. Each species of human relative was a neat, single branch. Ancient tooth proteins suggest Homo erectus may have left genetic legacy in people today As an undergraduate, I was taught that Homo sapiens was one of these branches that emerged in Africa, spread across the world, and displaced every archaic human it encountered. Neanderthals, Homo erectus, and other ancient relatives were evolutionary dead ends – unfortunate cousins who left no descendants. In the 30 years since I left university, those early lessons are now radically revised. That neat replacement story is now comprehensively wrong, largely thanks to studies like the one published in Nature this week by Qiaomei Fu from the Chinese Academy of Sciences and colleagues. The paper achieves something that would have seemed impossible a decade ago: it recovers meaningful biological information from H. erectus fossils far too old for DNA. Instead of genetic sequences, the team extracted ancient proteins from the enamel of six teeth from three Chinese sites – Zhoukoudian , Hexian and Sunjiadong – all dating to around 400,000 years ago. Homo erectus is widely regarded as the first hominin to leave Africa; the evidence suggests this species had moved into Eurasia nearly two million years ago. It remains the most geographically widespread human ancestor that ever lived. The new study indicates that Homo erectus exchanged genes with Denisovans in East Asia roughly 400,000 years ago. The study suggests that some of that genetic legacy, it now appears, was passed on to living people in the Philippines, Papua New Guinea, and across south-east Asia. Tooth enamel is the hardest tissue in the body, and its proteins survive long after DNA has degraded beyond recovery. What the team found in those proteins is striking. All six specimens share a previously unknown amino acid variant – a tiny molecular signature, a single letter changed in the protein sequence, never seen in any other hominin alive or dead. This variant clusters these East Asian H. erectus into a distinct group, confirming their identity and settling a long-running debate about whether the unusual Hexian fossils were H. erectus at all. A second variant they share, however, is not unique to H. erectus. It also appears in Denisovans – a mysterious archaic human group known mainly from a cave in Siberia. The corresponding genetic variant turns up in living people at frequencies of 21 per cent in the Philippines and about 1 per cent in India, distributed in a pattern that matches what we'd expect if it entered modern humans via Denisovan ancestry. The most reasonable interpretation is that H. erectus populations in east Asia passed this variant to Denisovans through interbreeding, and Denisovans later passed it on to the ancestors of modern south-east Asians and Oceanians. This transfer of genetic material from one species to another is known as introgression. The lineage we once thought was a dead end has, it turns out, left a small but detectable trace in living human genomes – a molecular thread connecting a Peking Man tooth to living people in Asia. A pattern repeated - But the significance of today's paper extends well beyond the specific variant or the specific populations involved. What it really shows is that interbreeding between archaic human lineages was not exceptional. It was routine. Every major hominin lineage we have been able to examine genomically shows admixture. Modern humans outside Africa carry roughly 2 per cent Neanderthal DNA. Papuans and Aboriginal Australians carry an additional 2–5 per cent Denisovan ancestry. West African populations carry genetic signatures from an unidentified archaic lineage. Even Denisovans themselves, as today's study adds further weight to, received gene flow from something older and more diverged - likely H. erectus. A 2019 review in the American Journal of Physical Anthropology documents at least three distinct introgression events from Denisovan-like populations into south-east Asian and Oceanic ancestors alone, some occurring as recently as 20,000 years ago. The picture is not one of clean lineages but of a tangled web of contact and exchange extending across millions of years. The implications are far-reaching. Our genomes are not the product of a single unbroken lineage emerging from Africa. They are mosaics, assembled from contributions by multiple archaic groups, each adapted to its own regional environment. Some of the Denisovan-derived variants in Papuan genomes, for instance, appear to influence immune function. The H. erectus-derived variant identified today has unknown functional consequences – that remains an open question – but the precedent from other gene variants that have introgressed suggests that adaptation to new environments may have been part of the story. Ghost populations Perhaps most intriguing is what the new paper implies about all the populations we cannot yet study. H. erectus survived in Indonesia until perhaps 100,000 years ago. Homo floresiensis, the diminutive "hobbit" species, was present on Flores when modern humans arrived. Another human lineage, Homo luzonensis, occupied the Philippines. None of these populations has yielded DNA, and until today, none has yielded any molecular data at all. Were they also absorbed, at least partially, into the human populations that replaced them? The genomic evidence from living people has not, so far, detected their signal clearly – but the tools available until recently were blunt instruments. The proteomic approach demonstrated in today's paper offers a way forward. If proteins can be recovered from H. erectus enamel at 400,000 years, the same approach applied to floresiensis or luzonensis material might finally reveal whether those lineages, too, contributed something to the humans who came after them. The old metaphor of a tree – a single trunk branching into distinct species – has been quietly replaced in the scientific literature. It might be better to consider the process as a braided river, with many channels running partly together and partly apart, exchanging water continuously. This new study is one more confirmation that when ancient human populations disappeared, they left traces of themselves behind. SKS SKS This article was generated from an automated news agency feed without modifications to text. Stay updated with US News covering politics, crime, weather, local events, and sports highlights. Get the latest on Donald Trump and American politics along with Horoscope 2026. Home/World News/Us News/Ancient Tooth Proteins Suggest Homo Erectus May Have Left Genetic Legacy In People Today See LessPoole , For most of the 20th century, the model of human origins was a tree: with the trunk dividing into branches, and then twigs. Each species of human relative was a neat, single branch.
As an undergraduate, I was taught that Homo sapiens was one of these branches that emerged in Africa, spread across the world, and displaced every archaic human it encountered.
Neanderthals, Homo erectus, and other ancient relatives were evolutionary dead ends – unfortunate cousins who left no descendants. In the 30 years since I left university, those early lessons are now radically revised.
That neat replacement story is now comprehensively wrong, largely thanks to studies like the one published in Nature this week by Qiaomei Fu from the Chinese Academy of Sciences and colleagues.
The paper achieves something that would have seemed impossible a decade ago: it recovers meaningful biological information from H. erectus fossils far too old for DNA.
Instead of genetic sequences, the team extracted ancient proteins from the enamel of six teeth from three Chinese sites – Zhoukoudian , Hexian and Sunjiadong – all dating to around 400,000 years ago.
Homo erectus is widely regarded as the first hominin to leave Africa; the evidence suggests this species had moved into Eurasia nearly two million years ago. It remains the most geographically widespread human ancestor that ever lived.
The new study indicates that Homo erectus exchanged genes with Denisovans in East Asia roughly 400,000 years ago.
The study suggests that some of that genetic legacy, it now appears, was passed on to living people in the Philippines, Papua New Guinea, and across south-east Asia.
Tooth enamel is the hardest tissue in the body, and its proteins survive long after DNA has degraded beyond recovery. What the team found in those proteins is striking. All six specimens share a previously unknown amino acid variant – a tiny molecular signature, a single letter changed in the protein sequence, never seen in any other hominin alive or dead.
This variant clusters these East Asian H. erectus into a distinct group, confirming their identity and settling a long-running debate about whether the unusual Hexian fossils were H. erectus at all. A second variant they share, however, is not unique to H. erectus.
It also appears in Denisovans – a mysterious archaic human group known mainly from a cave in Siberia. The corresponding genetic variant turns up in living people at frequencies of 21 per cent in the Philippines and about 1 per cent in India, distributed in a pattern that matches what we'd expect if it entered modern humans via Denisovan ancestry.
The most reasonable interpretation is that H. erectus populations in east Asia passed this variant to Denisovans through interbreeding, and Denisovans later passed it on to the ancestors of modern south-east Asians and Oceanians. This transfer of genetic material from one species to another is known as introgression.
The lineage we once thought was a dead end has, it turns out, left a small but detectable trace in living human genomes – a molecular thread connecting a Peking Man tooth to living people in Asia.
A pattern repeated
-
But the significance of today's paper extends well beyond the specific variant or the specific populations involved. What it really shows is that interbreeding between archaic human lineages was not exceptional. It was routine.
Every major hominin lineage we have been able to examine genomically shows admixture. Modern humans outside Africa carry roughly 2 per cent Neanderthal DNA. Papuans and Aboriginal Australians carry an additional 2–5 per cent Denisovan ancestry.
West African populations carry genetic signatures from an unidentified archaic lineage. Even Denisovans themselves, as today's study adds further weight to, received gene flow from something older and more diverged - likely H. erectus.
A 2019 review in the American Journal of Physical Anthropology documents at least three distinct introgression events from Denisovan-like populations into south-east Asian and Oceanic ancestors alone, some occurring as recently as 20,000 years ago.
The picture is not one of clean lineages but of a tangled web of contact and exchange extending across millions of years.
The implications are far-reaching. Our genomes are not the product of a single unbroken lineage emerging from Africa. They are mosaics, assembled from contributions by multiple archaic groups, each adapted to its own regional environment.
Some of the Denisovan-derived variants in Papuan genomes, for instance, appear to influence immune function. The H. erectus-derived variant identified today has unknown functional consequences – that remains an open question – but the precedent from other gene variants that have introgressed suggests that adaptation to new environments may have been part of the story.
Ghost populations
Perhaps most intriguing is what the new paper implies about all the populations we cannot yet study. H. erectus survived in Indonesia until perhaps 100,000 years ago. Homo floresiensis, the diminutive "hobbit" species, was present on Flores when modern humans arrived. Another human lineage, Homo luzonensis, occupied the Philippines.
None of these populations has yielded DNA, and until today, none has yielded any molecular data at all. Were they also absorbed, at least partially, into the human populations that replaced them?
The genomic evidence from living people has not, so far, detected their signal clearly – but the tools available until recently were blunt instruments.
The proteomic approach demonstrated in today's paper offers a way forward. If proteins can be recovered from H. erectus enamel at 400,000 years, the same approach applied to floresiensis or luzonensis material might finally reveal whether those lineages, too, contributed something to the humans who came after them.
The old metaphor of a tree – a single trunk branching into distinct species – has been quietly replaced in the scientific literature. It might be better to consider the process as a braided river, with many channels running partly together and partly apart, exchanging water continuously.
This new study is one more confirmation that when ancient human populations disappeared, they left traces of themselves behind. SKS
SKS
This article was generated from an automated news agency feed without modifications to text.
Source: HindustanTimes
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